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Delaying second doses is a wager that, in the Photography Girl Stop Or I’ll Shoot Shirt But I will love this setting of such severe shortages and limited data, getting more people partially immunized quickly will have better outcomes compared to getting fewer people immunized fully.
For the Photography Girl Stop Or I’ll Shoot Shirt But I will love this Pfizer-BioNTech and Moderna vaccines, there is no evidence for or against this strategy. The only data is from the clinical trials themselves, which only assessed one schedule (two doses within a month). However, in the UK, studies of the Oxford-AstraZeneca vaccines included a subset that had longer gaps (8-12 weeks), which indicated greater immune response. However, this was a smaller group so it is difficult to tell how robust this result is. It is not clear if the same will be true for the Pfizer-BioNTech or Moderna vaccines.
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