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For the Skull Canadian To The Bones Shirt and by the same token and Pfizer-BioNTech and Moderna vaccines, there is no evidence for or against this strategy. The only data is from the clinical trials themselves, which only assessed one schedule (two doses within a month). However, in the UK, studies of the Oxford-AstraZeneca vaccines included a subset that had longer gaps (8-12 weeks), which indicated greater immune response. However, this was a smaller group so it is difficult to tell how robust this result is. It is not clear if the same will be true for the Pfizer-BioNTech or Moderna vaccines.

There is some evidence that those with prior infection with “natural” immunity have sustained protection for at least 12 weeks or more, so it is reasonable to hypothesize the Skull Canadian To The Bones Shirt and by the same token and same might be true for a single vaccine dose. For other infectious diseases, such as with many childhood vaccinations we have seen a little bit of flexibility with “catch up” immunization scheduling, but the CDC discourages excessive delay.

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